Autophagy and Protein Quality Control in Parkinson’s Disease
Authors: Martinez-Vicente M, Vila M
Journal: Cold Spring Harbour Perspectives in Medicine
Reference: 16(3):a041619
Year: 2026
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Authors: Martinez-Vicente M, Vila M
Journal: Cold Spring Harbour Perspectives in Medicine
Reference: 16(3):a041619
Year: 2026
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Blood-brain-barrier opening with low-intensity focused ultrasound reduces neuromelanin accumulation in a non-human primate model.
Authors: Esteban-García N, Martín-Flórez C, Pineda-Pardo JA, López-Aguirre M, Carrillo M, Rodríguez-Rojas R, Lanciego JL, Vila M, Obeso JA, Blesa J.
Journal: Brain
Reference: In press
Year: 2026
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Cell-based regenerative interventions in Parkinson’s disease: Overcoming pharmacological limitations
Authors: Padilla AL, Lanciego JL, Vila M, de Castro F, Pozo D, Rodríguez de Fonseca F, Serrano A, Sáez-Valero J, Núñez L, Villalobos C, Tapias V.
Journal: Acta Pharmaceutica Sinica B
Reference: 16(5):2645-2681
Year: 2026
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Divergent tau pathology profiles induced by distinct alpha synuclein aggregates in non-human primates
Authors: Darricau M, Neu-Faber C, Bourdenx M, Dovero S, Porras G, Thiolat ML, Trigo-Damas I, Garcia-Carrillo N, Herrero MT, Vila M, Obeso JA, Planche V, Bezard E, Dehay B.
Journal: Brain
Reference: In press
Year: 2026
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Effects of neuromelanin buildup in rodent nigral dopamine neurons: implications for sex-biased vulnerability in Parkinson’s disease
Authors: D’Addario SL, Massaro Cenere M, Cossa F, Scaricamazza S, Nesci V, D’Ottavio G, Caprioli D, Ferri A, Vila M, Ledonne A, Mercuri ND.
Journal: Neurobiology of Disease
Reference: 223:107378
Year: 2026
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Introducing PIGMO, a novel PIGmented MOuse model of Parkinson’s disease
Authors: Chocarro J, Marana S, Espelosin M, Rico AJ, Ariznabarreta G, Lorenzo-Ramos E, Ilarduya MM, Hernandez-Alcoceba R, Chillón M, Vila M, Kordower JH, Schapira AHV, Garcia-Osta A, Cuadrado-Tejedor MDM, Lanciego JL
Journal: npj Parkinson's Disease
Reference: 12(1):72
Year: 2026
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Response to: Neuromelanin? T 1 shortening is a necessary condition
Authors: Pérot JB, Gonzalez-Sepulveda M, Vila M, Lehéricy S.
Journal: Brain Communications
Reference: 8(3):fcag215
Year: 2026
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The Vall d’Hebron Initiative for Parkinson (VHIP) cohort: a prospective, longitudinal, and observational study enrolling de novo Parkinson’s disease patients for biomarker identification and validation
Authors: Samaniego D, Enríquez-Calzada S, Domingo L, Armengol M, Camprodón M, Melgarejo Martínez L, Arrúe-Gonzalo M, Miret-Milian M, González V, Belmonte S, Lucas-Del-Pozo S, Xicoy H, López Carrasco A, Riera J, Pradas E, Castillo-Sánchez P, Montpeyó M, Montpeyó D, Zapata MA, Vila M, Martínez-Vicente M*, Laguna A*, Hernández-Vara J*.
Journal: Frontiers in Aging Neuroscience
Reference: Volume 18
Year: 2026
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Age-dependent progression from clearance to vulnerability in the early response of periventricular microglia to α-synuclein toxic species
Authors: Sirerol-Piquer MS, Perez-Villalba A, Duart-Abadia P, Belenguer G, Gómez-Pinedo U, Blasco-Chamarro L, Carrillo-Barberà P, Pérez-Cañamás A, Navarro-Garrido V, Dehay B, Vila M, Vitorica J, Pérez-Sánchez F, Fariñas I
Journal: Molecular Neurodegeneration
Reference: 20(1):26
Year: 2025
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Autophagy beyond Earth: Dr. Ghada Alsaleh on aging, cells, and space
Authors: Mari M, Martinez-Vicente M
Journal: Autophagy
Reference: 22(3):627–629
Year: 2025
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Chaperone-mediated autophagy sustains muscle stem cell regenerative functions but declines with age
Authors: Ramírez-Pardo I, Campanario S, Chavda B, Santiago-Fernández O, Flández M, Grima-Terrén M, Cisneros A, Calls-Cobos A, Itzhak DN, Ngo B, Janaki-Raman S, Kantz ED, Ortet L, Diaz A, Lindenau K, Doménech-Fernández J, Gómez-Cabrera MC, Camafeita E, Vázquez J, Martinez-Vicente M, Serrano AL, Perdiguero E, Isern J, Cuervo AM, Muñoz-Cánoves P
Journal: Nature Metabolism
Reference: 7(12):2571-2588
Year: 2025
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Differential pathological dynamics triggered by distinct Parkinson patient-derived α-synuclein extracts in nonhuman primates
Authors: Kinet R, Bourdenx M, Dovero S, Darricau M, Arotcarena ML, Camus S, Porras G, Thiolat ML, Trigo-Damas I, Bohic S, Morari M, Doudnikoff E, Goikoetxea M, Claverol S, Tokarski C, Kruse N, Mollenhauer B, Estrada C, Garcia-Carrillo N, Herrero MT, Vila M, Obeso JA, Bezard E, Dehay B.
Journal: Science Advances
Reference: 11(25):eadu6050
Year: 2025
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Dysfunctional LHX6 pallido-subthalamic projections mediate epileptic events in a mouse model of Leigh Syndrome
Authors: Sánchez-Benito L, González-Torres M, Fernández-González I, Cutando L, Royo M, Compte J, Vila M, Jurado S, Sanz E, Quintana A
Journal: Journal of Clinical Investigation
Reference: 135(23):e187571
Year: 2025
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Longitudinal neuromelanin changes in prodromal and early Parkinson’s disease in humans and rat model
Authors: Pérot JB, Ruze A, Gaurav R, Rebbah S, Cadin C, Le Troter A, Soustelle L, Mouton L, Valabrègue R, Parent A, Mangone G, Lejeune FX, Arnulf I, Corvol JC, Vidailhet M, Santin MD, Vila M, Lehéricy S.
Journal: Brain Communications
Reference: 7(3):fcaf204
Year: 2025
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LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease mode
Authors: Blasco-Agell L, Pons-Espinal M, Testa V, Roch G, Montero-Muñoz J, Fernandez-Carasa I, Baruffi V, Gonzalez-Sepulveda M, Richaud-Patin Y, Jimenez S, Cuadros T, Cladera-Sastre JM, Compte J, Manglano-Artuñedo Z, Ventura S, Juan-Otero M, Tolosa E, Raya A*, Vila M*, Consiglio A*
Journal: Communications Biology
Reference: 8(1):1203
Year: 2025
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Neuromelanin and selective neuronal vulnerability to Parkinson’s disease
Authors: Filimontseva A, Fu Y, Vila M, Halliday GM
Journal: Trends in Neurosciences
Reference: 48(6):445-459
Year: 2025
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Neuromelanin: Bridging catecholamine metabolism and neurodegeneration in Parkinson’s disease
Authors: Gonzalez-Sepulveda M, Cladera-Sastre JM, Vila M
Journal: Handbook of Behavioral Neuroscience
Reference: 35:21-42
Year: 2025
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Phenotypic characterization of an Atp13a2 knockout rat model of Parkinson’s disease
Authors: Kinet R, Sikora J, Arotcarena ML, Decourt M, Balado E, Doudnikoff E, Bohic S, Thiolat ML, Dutheil N, Mazzocco C, Harhouri K, Steinschneider R, Menoret S, Tesson L, Anegon I, Morari M, Vila M, Georges F, Bezard E, Fernagut PO, Dehay B
Journal: npj Parkinson’s Disease
Reference: 11(1):321
Year: 2025
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Single-cell transcriptomics for immune profiling of cerebrospinal fluid in neurological diseases
Authors: Ramos-Vicente D, Monterosso P, de Fàbregues O, Roch G, Vila M, Bové J
Journal: Frontiers in Immunology
Reference: 16:1599303
Year: 2025
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Standardised TruAI automated quantification of intracellular neuromelanin granules in human brain tissue sections
Authors: Filimontseva A, Cuadros T, Chatterton Z, Burke A, Mahabadian AA, Compte J, Fu Y, Vila M*, Halliday GM*
Journal: Neuropathology and Applied Neurobiology
Reference: 51(4):e70033
Year: 2025
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Systematic Assessment of Matrix Effect, Recovery, and Process Efficiency Using Three Complementary Approaches: Implications for LC-MS/MS Bioanalysis Applied to Glucosylceramides in Human Cerebrospinal Fluid
Authors: Castillo-Ribelles L, Arranz-Amo JA, Hernandez-Vara J, Ferrer-Costa R, Martínez-Vicente M*, Carnicer-Caceres C*
Journal: ACS Omega
Reference: 10(44):52449-52458
Year: 2025
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The Human Microglia Atlas (HuMicA) Unravels Changes in Homeostatic and Disease-Associated Microglia Subsets across Neurodegenerative Conditions
Authors: Martins-Ferreira R, Calafell-Segura J, Leal B, Rodríguez-Ubreva J, Martínez-Saez E, Mereu E, Pinhoe Costa P, Laguna A, Ballestar E
Journal: Nature Communications
Reference: 16:739
Year: 2025
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ZSCAN21 mediates the pathogenic transcriptional induction of α-synuclein in cellular and animal models of Parkinson’s disease
Authors: Kozoriz A, Mora S, Damiano MA, Carballo-Carbajal I, Parent A, Kumarasinghe L, Vila M, Lassot I, Desagher S
Journal: Cell Death & Disease
Reference: 16(1):394
Year: 2025
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Basic Science in Movement Disorders: Fueling the Engine of Translation into Clinical Practice
Authors: Outeiro TF, Kalia LV, Bezard E, Ferrario J, Lin CH, Salama M, Standaert DG, Taiwo L, Takahashi R, Vila M, Mollenhauer B, Svenningsson P
Journal: Movement Disorders
Reference: 39(6):929-933
Year: 2024
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Clusterin deficiency is associated with a lack of response to teriflunomide in multiple sclerosis
Authors: Malhotra S, Fissolo N, Rodríguez-Rivera C, Monreal E, Montpeyo M, Urcelay E, Triviño JC, Pérez-García MJ, Segura MF, Pappolla A, Río J, Vilaseca A, Fernández Velasco JI, Miguez A, Goicoechea C, Martinez-Vicente M, Villar LM, Montalban X, Comabella M
Journal: Clinical and Translational Medicine
Reference: 14(4):e1654
Year: 2024
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CSF d18:1 sphingolipid species in Parkinson disease and dementia with Lewy bodies with and without GBA1 variants
Authors: Lerche S, Wurster I, Valente EM, Avenali M, Samaniego D, Martínez-Vicente M, Hernández-Vara J, Laguna A, Sturchio A, Svenningsson P, France NP, Barlow C, Sankaranarayanan S, Brockmann K
Journal: npj Parkinson's Disease
Reference: 10(1):198
Year: 2024
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Developing Allosteric Chaperones for GBA1-Associated Disorders-An Integrated Computational and Experimental Approach
Authors: Montpeyo M, Pérez-Carmona N, Cubero E, Delgado A, Ruano A, Carrillo J, Bellotto M, Martinez-Vicente M*, Garcia-Collazo AM*
Journal: International Journal of Molecular Sciences
Reference: 26(1):9
Year: 2024
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Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy
Authors: Gordaliza-Alaguero I, Sànchez-Fernàndez-de-Landa P, Radivojevikj D, Villarreal L, Arauz-Garofalo G, Gay M, Martinez-Vicente M, Seco J, Martín-Malpartida P, Vilaseca M, Macías MJ, Palacin M, Ivanova S, Zorzano A.
Journal: Autophagy
Reference: 21(5):957-978.
Year: 2024
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Evaluation of a Liquid Chromatography-Tandem Mass Spectrometry Method for the Analysis of Glucosylceramide and Galactosylceramide Isoforms in Cerebrospinal Fluid of Parkinson’s Disease Patients
Authors: Castillo-Ribelles L, Arranz-Amo JA, Hernández-Vara J, Samaniego-Toro D, Enriquez-Calzada S, Pozo SL, Camprodon-Gomez M, Laguna A, Gonzalo MA, Ferrer R, Martinez-Vicente M, Carnicer-Caceres C
Journal: Analytical Chemistry
Reference: 96(31):12875-12882
Year: 2024
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Modelling human brain-wide pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits
Authors: Laguna A, Peñuelas N, Gonzalez-Sepulveda M, Nicolau A, Arthaud S, Guillard-Sirieix C, Lorente-Picón M, Compte J, Miquel-Rio L, Xicoy H, Liu J, Parent A, Cuadros T, Romero-Giménez J, Pujol G, Giménez-Llort L, Fort P, Bortolozzi A, Carballo-Carbajal I, Vila M
Journal: Nature Communications
Reference: 15(1):8819
Year: 2024
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The Role of Chaperone-Mediated Autophagy in Tissue Homeostasis and Disease Pathogenesis
Authors: Valdor R, Martinez-Vicente M
Journal: Biomedicines
Reference: 12(2):257
Year: 2024
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Adult-specific Reelin expression alters striatal neuronal organization: implications for neuropsychiatric disorders
Authors: Pardo M, Gregorio S, Montalban E, Pujadas L, Elias-Tersa A, Masachs N, Vílchez-Acosta A, Parent A, Auladell C, Girault JA, Vila M, Nairn AC, Manso Y, Soriano E
Journal: Frontiers in Cellular Neuroscience
Reference: 17:1143319
Year: 2023
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Cortical Lewy body injections induce long-distance pathogenic alterations in the non-human primate brain
Authors: Teil M, Dovero S, Bourdenx M, Arotcarena ML, Darricau M, Porras G, Thiolat ML, Trigo-Damas I, Perier C, Estrada C, Garcia-Carrillo N, Herrero MT, Vila M, Obeso JA, Bezard E, Dehay B
Journal: npj Parkinson’s Disease
Reference: 9(1):135
Year: 2023
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In vivo reduction of age-dependent neuromelanin accumulation mitigates features of Parkinson’s disease
Authors: Gonzalez-Sepulveda M, Compte J, Cuadros T, Nicolau A, Guillard-Sirieix C, Peñuelas N, Lorente-Picon M, Parent A, Romero-Giménez J, Cladera-Sastre JM, Laguna A, Vila M.
Journal: Brain
Reference: 146(3):1040-1052
Year: 2023
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Investigating the impact of physical activity on mitochondrial function in Parkinson’s disease (PARKEX): Study protocol for A randomized controlled clinical trial
Authors: Magaña JC, Deus CM, Baldellou L, Avellanet M, Gea-Rodríguez E, Enriquez-Calzada S, Laguna A, Martínez-Vicente M, Hernández-Vara J, Giné-Garriga M, Pereira SP, Montane J.
Journal: PLoS One
Reference: 18(11):e0293774
Year: 2023
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Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates
Authors: Chocarro J, Rico AJ, Ariznabarreta G, Roda E, Honrubia A, Collantes M, Peñuelas I, Vázquez A, Rodríguez-Pérez AI, Labandeira-García JL, Vila M, Lanciego JL
Journal: Brain
Reference: 146(12):5000-5014
Year: 2023
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Relevance of tissue‐resident memory CD8 T cells in the onset of Parkinson’s disease and examination of its possible etiologies: infectious or autoimmune?
Authors: de Fàbregues O, Sellés M, Ramos‐Vicente D, Roch G, Vila M, Bové J
Journal: Neurobiology of Disease
Reference: 187:106308
Year: 2023
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Sex Differences in Motor and Non-Motor Symptoms Among Spanish Patients with Parkinson’s Disease
Authors: Diego Santos-García, Ariadna Laguna, Jorge Hernández-Vara, Teresa de Deus Fonticoba, Carlos Cores Bartolomé, Maria J Feal Painceiras, Maria Cristina Íñiguez-Alvarado, Iago García Díaz, Silvia Jesús, Maria Teresa Boungiorno, Lluís Planellas, Marina Cosgaya, Juan García Caldentey, Nuria Caballol, Ines Legarda, Iria Cabo, Lydia López Manzanares, Isabel González Aramburu, Maria A Ávila Rivera, Víctor Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Julio Dotor García-Soto, Carmen Borrué, Berta Solano Vila, María Álvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C Martínez Castrillo, Pilar Sánchez Alonso, Maria G Alonso Losada, Nuria López Ariztegui, Itziar Gastón, Jaime Kulisevsky, Manuel Menéndez González, Manuel Seijo, Javier Rúiz Martínez, Caridad Valero, Mónica Kurtis, Jessica González Ardura, Ruben Alonso Redondo, Carlos Ordás, Luis M López Díaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir,
Journal: Journal of Clinical Medicine
Reference: 12(4):1329
Year: 2023
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The Consequences of GBA Deficiency in the Autophagy-Lysosome System in Parkinson’s Disease Associated with GBA
Authors: Pradas E, Martinez-Vicente M
Journal: Cells
Reference: Jan 3;12(1):191
Year: 2023
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Brain injections of glial cytoplasmic inclusions induce a multiple system atrophy-like pathology
Authors: Teil M, Dovero S, Bourdenx M, Arotcarena ML, Camus S, Porras G, Thiolat ML, Trigo-Damas I, Perier C, Estrada C, Garcia-Carrillo N, Morari M, Meissner WG, Herrero MT, Vila M, Obeso JA, Bezard E, Dehay B.
Journal: Brain
Reference: 145(3):1001-1017
Year: 2022
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Human α-synuclein overexpression in mouse serotonin neurons triggers a depressive-like phenotype. Rescue by oligonucleotide therapy
Authors: Miquel-Rio L, Alarcón-Arís D, Torres-López M, Cóppola-Segovia V, Pavia-Collado R, Paz V, Ruiz-Bronchal E, Campa L, Casal C, Montefeltro A, Vila M, Artigas F, Revilla R, Bortolozzi A
Journal: Translational Psychiatry
Reference: 12(1):79
Year: 2022
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Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology
Authors: Navarro-Romero A, Fernandez-Gonzalez I, Riera J, Montpeyo M, Albert-Bayo M, Lopez-Royo T, Castillo-Sanchez P, Carnicer-Caceres C, Arranz-Amo JA, Castillo-Ribelles L, Pradas E, Casas J, Vila M, Martinez-Vicente M.
Journal: npjParkinson’s Disease
Reference: 8(1):126
Year: 2022
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Spontaneous changes in brain striatal dopamine synthesis and storage dynamics ex vivo reveal end-product feedback-inhibition of tyrosine hydroxylase
Authors: González-Sepúlveda M, Omar MY, Hamdon S, Ma G, Rosell-Vilar S, Raivio N, Abass D, Martínez-Rivas A, Vila M, Giraldo J, Carrascal M, Abián J, Gil C, Sabriá J, Ortiz J, Moreno-Delgado D.
Journal: Neuropharmacology
Reference: 212:109058
Year: 2022
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Bioinspired theranostic coordination polymer nanoparticles for intranasal dopamine-replacement in Parkinson’s disease
Authors: García-Pardo J, Novio F, Nador F, Cavaliere I, Suarez-Garcia S, Lope-Piedrafita S, Candiota AP, Romero J, Rodriguez B, Bove J, Vila M, Lorenzo-Rivera J, Ruiz-Molina D
Journal: ACS Nano
Reference: 15(5):8592-8609
Year: 2021
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Authors: Klionsky DJ, Martinez-Vicente, Vila M et al.
Journal: Autophagy
Reference: 17(1):1-382
Year: 2021
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Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease
Authors: Franco-Iborra S, Montpeyó M, Plaza-Zabala A, Sebastian D, Vila M, Martinez-Vicente M.
Journal: Autophagy
Reference: 17(3):672-689
Year: 2021
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Nurr1 repression mediates cardinal features of Parkinson’s Disease in α-synuclein transgenic mice.
Authors: Argyrofthalmidou M, Spathis AD, Maniati M, Poula A, Katsianou MA, Sotiriou E, Manousaki M, Perier C, Papapanagiotou I, Papadopoulou-Daifoti Z, Pitychoutis PM, Alexakos P, Vila M, Stefanis L, Vassilatis DK.
Journal: Human Molecular Genetics
Reference: 30(16):1469-1483
Year: 2021
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Serum metabolic biomarkers for synucleinopathy conversion in isolated REM sleep behavior disorder.
Authors: Laguna A, Xicoy H, Tolosa E, Serradell M, Vilas D, Gaig C, Fernandez M, Yanes O, Santamaria J, Amigó N, Iranzo A, Vila M.
Journal: npj Parkinson’s Disease
Reference: 7(1):40
Year: 2021
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The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson’s disease
Authors: Rabaneda-Lombarte N, Serratosa J, Bové J, Vila M, Saura J, Solà C.
Journal: Journal of Neuroinflammation
Reference: 18(1):88
Year: 2021
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The spatiotemporal changes in dopamine, neuromelanin and iron characterising Parkinson’s disease
Authors: Biondetti E, Santin MD, Valabrègue R, Mangone G, Gaurav R, Pyatigorskaya N, Hutchison M, Yahia-Cherif L, Villain N, Habert MO, Arnulf I, Leu-Semenescu S, Dodet P, Vila M, Corvol JC, Vidailhet M, Lehéricy S
Journal: Brain
Reference: 144(10):3114-3125
Year: 2021
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Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson’s disease-like mouse model and in monkeys
Authors: Alarcón-Arís D, Pavia-Collado R, Miquel-Rio L, Coppola-Segovia V, Ferrés-Coy A, Ruiz-Bronchal E, Galofré M, Paz V, Campa L, Revilla R, Montefeltro A, Kordower JH, Vila M, Artigas F, Bortolozzi A
Journal: eBioMedicine
Reference: 59:102944
Year: 2020
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Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in nonhuman primates
Authors: Arotcarena ML, Dovero S, Prigent A, Bourdenx M, Camus S, Porras G, Thiolat ML, Tasselli M, Aubert P, Kruse N, Mollenhauer B, Trigo Damas I, Estrada C, Garcia-Carrillo N, Vaikath NN, El-Agnaf OMA, Herrero MT, Vila M, Obeso JA, Derkinderen P, Dehay B, Bezard E
Journal: Brain
Reference: 143(5):1462–75
Year: 2020
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CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson’s disease
Authors: Galiano-Landeira J, Torra A, Vila M, Bové J
Journal: Brain
Reference: 143(12):3717-33
Year: 2020
See publication
Chitinase 3-like 1 is neurotoxic in primary cultured neurons
Authors: Matute-Blanch C, Calvo-Barreiro L, Carballo-Carbajal I, Gonzalo R, Sanchez A, Vila M, Montalban X, Comabella M
Journal: Scientific Reports
Reference: 10(1):7118
Year: 2020
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Identification of of distinc pathological signatures induced by patient-derived alpha-synuclein structures in non-human primates
Authors: 14. Bourdenx M, Nioche A, Dovero S, Arotcarena ML, Camus S, Porras G, Thiolat ML, Rougier NP, Prigent A, Aubert P, Bohic S, Sandt C, Laferrière F, Doudnikoff E, Kruse N, Mollenhauer B, Novello S, Morari M, Leste-Lasserre T, Trigo Damas I, Goillandeau M, Perier C, Estrada C, Garcia-Carrillo N, Recasens A, Vaikath NN, El-Agnaf OMA, Herrero MT, Derkinderen P, Vila M, Obeso JA, Dehay B, Bezard E
Journal: Science Advances
Reference: 6(20):eaaz9165
Year: 2020
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LRRK2 in Parkinson disease: challenges of clinical trials
Authors: Tolosa E, Vila M, Klein C, Rascol O
Journal: Nature Reviews Neurology
Reference: 16(2):97-107
Year: 2020
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Sex-dependent Calcium Hyperactivity Due to Lysosomal-Related Dysfunction in Astrocytes From APOE4 Versus APOE3 Gene Targeted Replacement Mice
Authors: Larramona-Arcas R, González-Arias C, Perea G, Gutiérrez A, Vitorica J, García-Barrera T, Gómez-Ariza JL, Pascua-Maestro R, Ganfornina MD, Kara E, Hudry E, Martinez-Vicente M, Vila M, Galea E, Masgrau R
Journal: Molecular Neurodegeneration
Reference: 15(1):35
Year: 2020
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Validation of a Reversed Phase UPLC-MS/MS Method to Determine Dopamine Metabolites and Oxidation Intermediates in Neuronal Differentiated SH-SY5Y Cells and Brain Tissue
Authors: Gonzalez-Sepulveda M, Laguna A, Carballo-Carbajal I, Galiano-Landeira J, Romero-Gimenez J, Cuadros T, Parent A, Peñuelas N, Compte J, Nicolau A, Guillard-Sirieix C, Xicoy H, Kobayashi J, Vila M.
Journal: ACS Chemical Neuroscience
Reference: 11(17):2679-87
Year: 2020
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Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
Authors: Carballo-Carbajal I, Laguna A, Romero-Gimenez J, Cuadros T, Bové J, Martinez-Vicente M, Parent A, Gonzalez-Sepulveda M, Peñuelas N, Torra A, Rodriguez-Galvan B, Ballabio A, Hasegawa T, Bortolozzi A, Gelpi E, Vila M
Journal: Nature Communications
Reference: 10(1):973
Year: 2019
See publication
Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology
Authors: Vila M, Laguna A, Carballo-Carbajal I
Journal: Autophagy
Reference: 15(11):2028-2030
Year: 2019
See publication
Neuromelanin, aging and neuronal vulnerability in Parkinson’s disease
Authors: Vila M
Journal: Movement Disorders
Reference: 34(10):1440-1451
Year: 2019
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Parkinson disease, substantia nigra vulnerability, and calbindin expression: Enlightening the darkness?
Authors: Blesa J, Vila M.
Journal: Movement Disorders
Reference: 34(2):161-163
Year: 2019
See publication
Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson’s disease
Authors: Franco-Iborra S, Cuadros T, Parent A, Romero-Gimenez J, Vila M*, Perier C*
Journal: Cell Death & Disease
Reference: 9(11):1122
Year: 2018
See publication
Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
Authors: Urrea L, Segura-Feliu M, Masuda-Suzukake M, Hervera A, Pedraz L, Aznar JM, Vila M, Samitier J, Torrents E, Ferrer I, Gavín R, Hagesawa M, Del Río JA
Journal: Molecular Neurobiology
Reference: 55(3):1847-1860
Year: 2018
See publication
Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients
Authors: Recasens A, Carballo-Carbajal I, Parent A, Bové J, Gelpi E, Tolosa E, Vila M.
Journal: Acta Neuropathologica Communications
Reference: 6(1):8
Year: 2018
See publication
Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson’s disease and Huntington’s disease
Authors: Franco-Iborra S, Vila M*, Perier C*
Journal: Frontiers in Neuroscience
Reference: 12:342
Year: 2018
See publication
Overexpression of TFEB drives a pleiotropic neurotrophic effect and prevents Parkinson’s disease-related neurodegeneration
Authors: Torra A, Parent A, Cuadros T, Rodríguez-Galván B, Ruiz-Bronchal E, Ballabio A, Bortolozzi A, Vila M*, Bové J*
Journal: Molecular Therapy
Reference: 26(6):1552-1567
Year: 2018
See publication
Selective alpha-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson disease
Authors: Alarcón-Arís D, Recasens A, Galofré M, Carballo-Carbajal I, Zacchi N, Ruiz-Bronchal E, Pavia-Collado R, Chica R, Ferrés-Coy A, Santos M, Revilla R, Montefeltro A, Fariñas I, Artigas F, Vila M*, Bortolozzi A*
Journal: Molecular Therapy
Reference: 26(2):550-567
Year: 2018
See publication
Synaptic regulator α-synuclein in dopaminergic fibers is essentially required for the maintenance of subependymal neural stem cells
Authors: Perez-Villalba A, Salomé Sirerol-Piquer M, Belenguer G, Soriano-Cantón R, Belén Muñoz-Manchado A, Villadiego J, Alarcón-Arís D, Soria FN, Dehay B, Bezard E, Vila M, Bortolozzi A, José Toledo-Aral J, Pérez-Sánchez F, Fariñas I
Journal: Journal of Neuroscience
Reference: 38(4):814-825
Year: 2018
See publication
The E3 ubiquitin-ligases TRIM17 and TRIM41 modulate α-synuclein expression by regulating ZSCAN21
Authors: Lassot I, Mora S, Lesage S, Zieba B, Coque E, Condroyer C, Bossowski JP, Mojsa B, Marelli C, Tesson C, Carballo-Carbajal I, Laguna A, Mangone G, Vila M, Brice A, Desagher S.
Journal: Cell Reports
Reference: 25(9):2484-2496.e9
Year: 2018
See publication
The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity
Authors: 29. Kim H, Calatayud C, Guha S, Fernández-Carasa I, Berkowitz L, Carballo-Carbajal I, Ezquerra M, Fernández-Santiago R, Kapahi P, Raya A, Miranda-Vizuete A, Lizcano JM, Vila M, Caldwell KA, Caldwell GA, Consiglio A, Dalfo E
Journal: Molecular Neurobiology
Reference: 55(9):7553-7554
Year: 2018
See publication
Cerebellar neurodegeneration in a new rat model of episodic hepatic encephalopathy
Authors: García-Lezana T, Oria M, Romero-Giménez J, Bové J, Vila M, Genescà J, Chavarria L and Cordoba J
Journal: Journal of Cerebral Blood Flow and Metabolism
Reference: 37(3):927-937
Year: 2017
See publication
Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration
Authors: Soria FN, Engeln M, Martinez-Vicente M, Glangetas C, Lopez-Gonzalez MJ, Dovero S, Dehay B, Normand E, Vila M, Favereaux A, Georges F, Lo Bianco C, Bezard E, Fernagut Po
Journal: Human Molecular Genetics
Reference: 26(14):2603-2615
Year: 2017
See publication
Alpha-synuclein propagation: New insights from animal models
Authors: Dehay B, Vila M, Bezard E, Brundin P, Kordower JH
Journal: Movement Disorders
Reference: 31(2):161-8
Year: 2016
See publication
Functional rescue of dopaminergic neuron loss in Parkinson’s disease mice after transplantation of hematopoietic stem and progenitor cells.
Authors: Altarche-Xifro W, di Vicino U, Muñoz-Martin MI, Bortolozzi A, Bové J, Vila M, Cosma MP
Journal: EBioMedicine
Reference: 8:83-95
Year: 2016
See publication
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Authors: Klionsky DJ, Martinez-Vicente, Vila M et al
Journal: Autophagy
Reference: 12(1):1-222
Year: 2016
See publication
The Parkinson disease mitochondrial hypothesis: where are we at?
Authors: Franco-Iborra S, Vila M, Perier C
Journal: Neuroscientist
Reference: 22(3):266-77
Year: 2016
See publication
Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson disease patients
Authors: Fernández-Santiago R, Carballo-Carbajal I, Castellano G, Torrent R, Richaud Y, Sánchez-Danés A, Vilarrasa R, Sánchez-Pla A, Mosquera JL, Soriano J, López-Barneo J, Canals JM, Alberch J, Raya A, Vila M, Consiglio A, Martín-Subero JI, Ezquerra M, Tolosa E
Journal: EMBO Molecular Medicine
Reference: 7(12):1529-46
Year: 2015
See publication
Targeting α-synuclein for treating Parkinson’s disease: mechanistic and therapeutic considerations
Authors: Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, Singleton A, Olanow CW, Merchant KM ,Bezard E, Petsko GA, Meissner WG
Journal: Lancet Neurology
Reference: 14(8):855-66
Year: 2015
See publication
BAX channel activity mediates lysosomal disruption linked to Parkinson disease
Authors: Bové J, Martínez-Vicente M., Dehay B, Perier C, Recasens A, Bombrun A, Antonsson B, Vila M
Journal: Autophagy
Reference: 10(5):889-900
Year: 2014
See publication
DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson’s disease
Authors: Barallobre MJ, Perier C, Bové J, Laguna A, Delabar JM, Vila M, Arbonés ML
Journal: Cell Death & Disease
Reference: 5:e1289
Year: 2014
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Lewy Body extracts from Parkinson’s Disease Brains trigger α-Synuclein Pathology and Neurodegeneration in Mice and Monkeys
Authors: Recasens A, Dehay B, Bové J, Carballo-Carbajal I, Dovero S, Pérez A, Fernagut PO, Blesa J, Parent A, Perier C, Fariñas I, Obeso JA, Bezard E, Vila M
Journal: Annals of Neurology
Reference: 75(3):351-62
Year: 2014
See publication
Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms
Authors: Perier C, Bender A, García-Arumí E, Melià MJ, Bové J, Laub C, Klopstock T, Elstner M, Mounsey RB, Teismann P, Prolla T, Andreu AL, Vila M
Journal: Brain
Reference: 136:2369-78
Year: 2013
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Alpha-synuclein and protein degradation pathways in Parkinson’s disease: A pathological feed-back loop
Authors: Martinez-Vicente M, Vila M
Journal: Experimental Neurology
Reference: 247:308-13
Year: 2013
See publication
Lysosomal impairment in Parkinson’s disease
Authors: Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, Klein C, Vila M, Bezard E
Journal: Movement Disorders
Reference: 28(6)725-32
Year: 2013
See publication
Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency
Authors: Ramonet D, Perier C, Recasens A, Dehay B, Bové J, Costa V, Scorrano L, Vila M.
Journal: Cell Death & Differentiation
Reference: 20(1):77-85
Year: 2013
See publication
Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson’s disease
Authors: Sánchez-Danés A, Richaud-Patin Y, Carballo-Carbajal I, Jiménez-Delgado S, Gaig C, Mora S, Di Guglielmo C, Ezquerra M, Patel B, Giralt A, Canals JM, Memo M, Alberch J, López-Barneo J, Vila M, Cuervo AM, Tolosa E, Consiglio A, Raya A
Journal: EMBO Molecular Medicine
Reference: 4(5):380-95
Year: 2012
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Efficient Generation of A9 Midbrain Dopaminergic Neurons by Lentiviral Delivery of LMX1A in Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
Authors: Sánchez-Danés A, Consiglio A, Richaud Y, Rodríguez-Pizà I, Dehay B, Edel M, Bové J, Memo M, Vila M, Raya A, Izpisua-Belmonte JC.
Journal: Human Gene Therapy
Reference: 23(1):56-69
Year: 2012
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Guidelines for the use and interpretation of assays for monitoring autophagy
Authors: Klionsky DJ, Martinez-Vicente M, Vila M et al
Journal: Autophagy
Reference: 8(4):445-544
Year: 2012
See publication
Loss of ATP13A2/PARK9 induces general lysosomal deficiency: implications for Parkinson’s disease
Authors: Dehay B, Ramirez A, Martinez-Vicente M, Perier C, Canron MH, Doudnikoff E, Vital A, Vila M, Klein C, Bezard E
Journal: Proceedings of the National Academy of Sciences USA
Reference: 109(24):9611-6
Year: 2012
See publication
Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove
Authors: Dehay B, Martinez-Vicente M, Ramirez A, Perier C, Klein C, Vila M, Bezard E
Journal: Autophagy
Reference: 8(9):1389-91
Year: 2012
See publication
Mitochondria and programmed cell death in Parkinson’s disease: apoptosis and beyond
Authors: Perier C, Bové J, Vila M
Journal: Antioxidants & Redox Signaling
Reference: 16(9):883-95
Year: 2012
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Mitochondrial biology and Parkinson’s disease
Authors: Perier C, Vila M
Journal: Cold Spring Harbor Perspectives in Medicine
Reference: 2(2):a009332
Year: 2012
See publication
Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
Authors: Xilouri M, Kyratzi E, Pitychoutis PM, Papadopoulou-Daifoti Z, Perier C, Vila M, Maniati M, Ulusoy A, Kirik D, Park DS, Wada K, Stefanis L
Journal: Human Molecular Genetics
Reference: 21(4):874-89
Year: 2012
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Fighting neurodegeneration with rapamycin: mechanistic insights
Authors: Bové J, Martínez-Vicente M, Vila M
Journal: Nature Reviews Neuroscience
Reference: 12(8):437-52
Year: 2011
See publication
Lysosomal membrane permeabilization in Parkinson’s Disease
Authors: Vila M, Bové J, Dehay B, Rodríguez-Muela N, Boya P
Journal: Autophagy
Reference: 7(1):98-100
Year: 2011
See publication
Oligomeric α-synuclein is toxic in vivo
Authors: Vila M
Journal: Movement Disorders
Reference: 26(9):1616
Year: 2011
See publication
Apoptosis inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins
Authors: Perier C, Bové J, Dehay, B, Jackson-Lewis V, Rabinovitch P., Przedborski, S, Vila M
Journal: Annals of Neurology
Reference: 68:184-192
Year: 2010
See publication
Pathogenic lysosomal depletion in Parkinson’s Disease
Authors: Dehay B, Bové J, Rodríguez-Muela N, Perier C, Recasens A, Boya P, Vila M
Journal: Journal of Neuroscience
Reference: 30(37):12535-12544
Year: 2010
See publication
Selective noradrenergic vulnerability in alpha-synuclein transgenic mice
Authors: Sotiriou E, Vassilatis DK, Vila M, Stefanis L
Journal: Neurobiology of Aging
Reference: 31(12):2103-14
Year: 2010
See publication
Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson’s disease
Authors: Hoang T, Choi DK, Nagai M, Wu DC, Nagata T, Prou D, Wilson GL, Vila M, Jackson-Lewis V, Dawson VL, Dawson TM, Chesselet MF, Przedborski S
Journal: Free Radical Biology and Medicine
Reference: 47(7):1049-56
Year: 2009
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Mitochondrial alterations in Parkinson’s disease: new clues
Authors: Vila M, Ramonet D, Perier C
Journal: Journal of Neurochemistry
Reference: 107:317-328
Year: 2008
See publication
Molecular pathways of programmed cell death in experimental Parkinson’s disease
Authors: Vila M, Perier C
Journal: Parkinsonism & Related Disorders
Reference: 14 Suppl 2:S176-9
Year: 2008
See publication
Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson’s disease
Authors: Perier C, Bove J, Wu DC, Jackson-Lewis V, Dehay B, Choi DG, Rathke-Hartlieb S, Bouillet P, Strasser A., Schulz JB, Przedborski S, Vila M
Journal: Proceedings of the National Academy of Sciences USA
Reference: 104(19):8161-6
Year: 2007
See publication
Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson’s disease
Authors: Choi DK, Pennathur S, Perier C, Tieu K, Teismann P., Wu DC, Jackson-Lewis V, Vila M, Von Sattel JP, Heinecke JW, Przedborski S
Journal: Journal of Neuroscience
Reference: 25(28):6594-600
Year: 2005
See publication
Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage
Authors: Perier C, Tieu K, Guegan C, Caspersen C, Jackson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S, Vila M
Journal: Proceedings of the National Academy of Sciences USA
Reference: 102(52):19126-19131
Year: 2005
See publication
Genetic clues to the pathogenesis of Parkinson’s disease
Authors: Vila M, Przedborski S
Journal: Nature Medicine
Reference: 10 Suppl:S58-62
Year: 2004
See publication
Interfering with programmed cell death in neurodegenerative diseases: insights from experimental animal models (Letter to Editor)
Authors: Vila M
Journal: Drug Discovery Today
Reference: 9(12):513-514
Year: 2004
See publication
JNK-mediated induction of COX-2 is required for neurodegeneration in a mouse model of Parkinson’s disease
Authors: Hunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, Rakic P, Flavell RA
Journal: Proceedings of the National Academy of Sciences USA
Reference: 101(2): 665-70
Year: 2004
See publication
Metabolic changes in the basal ganglia of patients with Huntington’s disease: an in situ hybridization study of cytochrome oxidase subunit I mRNA
Authors: Gourfinkel-An I, Vila M, Faucheux B, Duyckaerts C, Viallet F, Hauw JJ, Brice A, Agid Y, Hirsch EC
Journal: Journal of Neurochemistry
Reference: 80(3):466-76
Year: 2004
See publication
MPTP as a Mitochondrial Neurotoxic Model of Parkinson’s disease
Authors: Przedborski S, Tieu K, Perier C, Vila M
Journal: Journal of Bioenergetics and Biomembranes
Reference: 36(4):375-9
Year: 2004
See publication
Neurodegeneration: what does it mean?
Authors: Vila M
Journal: Neurología
Reference: 19(3):89-91
Year: 2004
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Apoptosis as therapeutic target
Authors: Vila M
Journal: Neurología
Reference: 18:186-193
Year: 2003
See publication
COX-2 and Neurodegeneration in Parkinson’s Disease
Authors: Teismann P, Vila M, Choi DK, Tieu K, Wu DC, Jackson-Lewis V, Przedborski S
Journal: Annals of the New York Academy of Sciences
Reference: 991:272-7
Year: 2003
See publication
Cyclooxygenase-2 is instrumental in Parkinson disease neurodegeneration
Authors: Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, Vila M, Jackson-Lewis V, Przedborski S
Journal: Proceedings of the National Academy of Sciences USA
Reference: 100(9):5473-8
Year: 2003
See publication
D-ß-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson’s disease
Authors: Tieu K, Caspersen C, Teismann P, Wu DC, Perier C, Naini A, Vila M, Jackson-Lewis V, Ramasamy R, Przedborski S
Journal: Journal of Clinical Investigation
Reference: 112(6):892-901
Year: 2003
See publication
Free radicals and nitric oxide toxicity in Parkinson’s disease
Authors: Przedborski S, Jackson-Lewis V, Vila M, Wu DC, Teismann P, Tieu K, Choi DG, Cohen O
Journal: Advances in Neurology
Reference: 91:83-94
Year: 2003
See publication
Neurodegeneration: what is it and where are we?
Authors: Przedborski S, Vila M, Jackson-Lewis V
Journal: Journal of Clinical Investigation
Reference: 111(1):3-10
Year: 2003
See publication
Neurotoxic contribution of NADPH oxidase-derived oxidative stress in the MPTP model of Parkinson’s disease
Authors: Wu DC, Teismann P, Tieu K, Vila M, Jackson-Lewis V, Ischiropoulos H, Przedborski S
Journal: Proceedings of the National Academy of Sciences USA
Reference: 100(10):6145-50
Year: 2003
See publication
Overexpression of HAHD II/ABAD rescues mitochondrial respiration and dopaminergic neurons in the MPTP model of Parkinson’s disease
Authors: Tieu K, Perier C, Vila M, Zhang HP, Teismann P, Caspersen C, Jackson-Lewis V, Stern DM, Yan SD, Przedborski S
Journal: Annals of Neurology
Reference: 56(1):51-60.
Year: 2003
See publication
Pathogenic role of glial cells in Parkinson’s Disease
Authors: Teismann P, Tieu K, Cohen O, Choi DK, Wu DC, Marks D, Vila M, Jackson-Lewis V, Przedborski S
Journal: Movement Disorders
Reference: 18(2):121-9
Year: 2003
See publication
Targeting programmed cell death in neurodegenerative diseases
Authors: Vila M, Przedborski S
Journal: Nature Reviews in Neuroscience
Reference: 4(5):365-75
Year: 2003
See publication
The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson’s disease
Authors: Przedborski S, Vila M
Journal: Annals of the New York Academy of Sciences
Reference: 991:189-98
Year: 2003
See publication
The rotenone model of Parkinson’s disease
Authors: Perier C, Bové J, Vila M, Przedborski S
Journal: Trends in Neuroscience
Reference: 26(7):345-6
Year: 2003
See publication
Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
Authors: Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S
Journal: Journal of Neuroscience
Reference: 22(5):1763-71
Year: 2002
See publication
Glial cell response: A pathogenic factor in Parkinson’s disease
Authors: Wu DC, Tieu K, Cohen O, Choi DK, Vila M, Jackson-Lewis V, Teismann P, Przedborski S
Journal: Journal of Neurovirology
Reference: 8:551-8
Year: 2002
See publication
Increased Expression and Redistribution of the Antiapoptotic Molecule Bcl-x(L) in Parkinson’sDisease
Authors: Hartmann A, Mouatt-Prigent A, Vila M, Abbas N, Perier C, Faucheux BA, Vyas S, Hirsch EC
Journal: Neurobiology of Disease
Reference: 10(1):28-32
Year: 2002
See publication
Instrumental activation of Bid by caspase-1 in a transgenic mouse model of ALS
Authors: Guegan C, Vila M, Teismann P, Chen C, Onténiente B, Li M, Friedlander RM, Przedborski S
Journal: Molecular and Cellular Neuroscience
Reference: 20(4):553-562
Year: 2002
See publication
Resistance of alpha-synuclein null mice to the parkinsonian neurotoxin MPTP
Authors: Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen K, Staal R, Tieu K, Schmitz Y, Yuan CA, Jackson-Lewis V, Hersch S, Sulzer D, Przedborski S, Burke R, Hen R
Journal: Proceedings of the National Academy of Sciences USA
Reference: 99:14524-14529
Year: 2002
See publication
Tyrosine hydroxylase
Authors: Jackson-Lewis V, Vila M, Przedborski S
Journal: Wiley Encyclopedia of Molecular Medicine
Reference: 3283-3293
Year: 2002
See publication
Bax ablation prevents dopaminergic neurodegeneration in the MPTP mouse model of Parkinson disease
Authors: Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, Offen D, Korsmeyer SJ, Przedborski S.
Journal: Proceedings of the National Academy of Sciences USA
Reference: 98(5):2837-42
Year: 2001
See publication
Engineered modeling and the secrets of Parkinson’s disease
Authors: Vila M, Wu DC, Przedborski S
Journal: Trends in Neuroscience
Reference: 24(11):S49-S55
Year: 2001
See publication
Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter
Authors: Matsuoka Y*, Vila M*, Lincoln S, McCormack A, Picciano M, LaFrancois J, Yu X, Dickson D, Langston WJ, McGowan E, Farrer M, Hardy J, Duff K, Przedborski S, Di Monte DA
Journal: Neurobiology of Disease
Reference: 8:535-539
Year: 2001
See publication
LY293558, an AMPA glutamate receptor antagonist, prevents and reverses levodopa-induced motor fluctuations in parkinsonian rats
Authors: Marin C, Jiménez A, Bonastre M, Vila M, Hirsch EC, Agid Y, Tolosa E
Journal: Synapse
Reference: 42(1): 40-47
Year: 2001
See publication
MPTP: a review of its mechanisms of neurotoxicity
Authors: Przedborski S, Vila M
Journal: Clinical Neuroscience Research
Reference: 1(6):407-418
Year: 2001
See publication
Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease
Authors: Przedborski S, Chen Q, Vila M, Giasson BI, Djaldetti R, Vukosavic S, Souza JM, Jackson-Lewis V, Lee VMY, Ischiropoulos H
Journal: Journal of Neurochemistry
Reference: 76:637-640
Year: 2001
See publication
Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis
Authors: Guegan C, Vila M, Rosoklija G, Hays AP, Przedborski S
Journal: Journal of Neuroscience
Reference: 21(17):6569-6576
Year: 2001
See publication
The last decade in Parkinson’s disease research: basic sciences
Authors: Przedborski S, Vila M
Journal: Advances in Neurology
Reference: 86:177-186
Year: 2001
See publication
The role of glial cells in Parkinson’s disease
Authors: Vila M, Jackson-Lewis V, Guegan C, Teismann P, Wu DC, Choi DG, Tieu K, Przedborski S
Journal: Current Opinion in Neurology
Reference: 14:483-489
Year: 2001
See publication
A new look at the pathogenesis of Parkinson’s disease
Authors: Przedborski S, Vila M, Jackson-Lewis V, Dawson TM
Journal: Trends in Pharmacological Sciences
Reference: 21(5):165
Year: 2000
See publication
Alpha-Synuclein upregulation in substantia nigra dopaminergic neurons following the administration of the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Authors: Vila M, Vukosavic S, Jackson-Lewis V, Jakowec M, Przedborski S
Journal: Journal of Neurochemistry
Reference: 74:721-729
Year: 2000
See publication
Developmental cell death in dopaminergic neurons of the substantia nigra of mice
Authors: Jackson-Lewis V, Vila M, Djaldetti R, Guegan C, Liberatore G, Liu J, O’Malley KL, Burke RE, Przedbosrki S
Journal: Journal of Comparative Neurology
Reference: 424(3):476-488
Year: 2000
See publication
Functional activity of zona incerta neurons is altered after nigrostriatal denervation in hemiparkinsonian rats
Authors: Perier C, Vila M, Feger J, Agid Y, Hirsch EC
Journal: Experimental Neurology
Reference: 162(1):215-224
Year: 2000
See publication
Metabolic activity of excitatory parafascicular and pedunculopontine inputs to subthalamic nucleus in a rat model of Parkinson’s disease
Authors: Orieux G, François C, Feger J, Yelnik J, Vila M, Ruberg M, Agid Y, Hirsch EC
Journal: Neuroscience
Reference: 97(1):79-88
Year: 2000
See publication
Metabolic changes in the basal ganglia following nigrostriatal denervation
Authors: Hirsch EC, Périer C, Orieux G, François C., Féger J, Yelnik J, Vila M, Levy R, Tolosa E, Marin C, Herrero MT, Obeso JA, Agid Y
Journal: Trends in Neuroscience
Reference: 23(10 Suppl):S78-85
Year: 2000
See publication
The indirect basal ganglia pathway in dopamine D(2) receptor-deficient mice
Authors: Murer MG, Dziewczapolski G, Saline P, Vila M, Tseng KY, Ruberg M, Rubinstein M, Kelly MA, Grandy DK, Low MJ, Hirsch EC, Raisman-Vozari R, Gershanik O
Journal: Neuroscience
Reference: 99(4):643-50
Year: 2000
See publication
The parkinsonian toxin MPTP: action and mechanism
Authors: Przedborski S, Jackson-Lewis V, Djaldetti R, Liberatore G, Vila M, Vukosavic S, Almer G
Journal: Restorative Neurology and Neuroscience
Reference: 16(2):135-142
Year: 2000
See publication
Time course changes in metabolic and electrophysiologic neuronal activity in the subthalamic nucleus of rats with unilateral lesion of the substantia nigra
Authors: Vila M, Perier C, Feger J, Yelnik J, Faucheux B, Ruberg M, Raisman-Vozari R, Agid Y, Hirsch EC
Journal: European Journal of Neuroscience
Reference: 12(1):337-344
Year: 2000
See publication
Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease
Authors: Liberatore GT, Jackson Lewis V, Vukosavic S, Mandir AS, Vila M, McAuliffe WJ, Dawson VL, Dawson TM, Przedborski S
Journal: Nature Medicine
Reference: 5(12):1403-1409
Year: 1999
See publication
Systemic administration of NMDA and AMPA receptor antagonists reverses the neurochemical changes induced by nigrostriatal denervation in basal ganglia
Authors: Vila M, Marin C, Ruberg M, Jimenez A, Raisman-Vozari R, Agid Y, Tolosa E, Hirsch EC
Journal: Journal of Neurochemistry
Reference: 73:344-352
Year: 1999
See publication
Consequences of nigrostriatal denervation on the functioning of the basal ganglia in human and non-human primates: an in situ hybridization study of cytochrome oxidase subunit I mRNA
Authors: Vila M, Levy R, Herrero MT, Ruberg M, Faucheux B, Obeso JA, Agid Y, Hirsch EC.
Journal: Journal of Neuroscience
Reference: 17(2):765-773
Year: 1997
See publication
Re-evaluation of the functional anatomy of the basal ganglia in normal and parkinsonian states
Authors: Levy R, Hazrati LN, Herrero MT, Vila M, Hassani OK, Mouroux M, Ruberg M, Asensi H, Agid Y, Féger J, Obeso JA, Parent A, Hirsch EC
Journal: Neuroscience
Reference: 76(2):335-343
Year: 1997
See publication
Consequences of nigrostriatal denervation on the GABAergic neurons of substantia nigra pars reticulata and superior colliculus in parkinsonian syndromes
Authors: Vila M, Herrero MT, Levy R, Faucheux B, Ruberg M, Guillen J, Luquin MR, Guridi J, Javoy-Agid F, Agid Y, Obeso JA, Hirsch EC
Journal: Neurology
Reference: 46:802-809
Year: 1996
See publication
Localization of monoamine oxidases in human peripheral tissues
Authors: Saura J, Nadal E, van den Berg B, Vila M, Bombi JA, Mahy N
Journal: Life Sciences
Reference: 59(16):1341-1349
Year: 1996
See publication
Metabolic activity of the basal ganglia in parkinsonian syndromes in human and non human primates: a cytochrome oxidase histochemistry study
Authors: Vila M, Levy R, Herrero MT, Faucheux B, Obeso JA, Agid Y, Hirsch EC
Journal: Neuroscience
Reference: 71 (4): 903-912
Year: 1996
See publication
Subthalamotomy in parkinsonian monkeys. Behavioural and biochemical analysis
Authors: Guridi J, Herrero MT, Luquin MR, Guillen J, Ruberg M, Laguna J, Vila M, Javoy-Agid F, Agid Y, Hirsch EC, Obeso JA
Journal: Brain
Reference: 119:1717-1727
Year: 1996
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Striatal expression of Methionine-enkephaline and substance P RNA messengers in Parkinson’s disease
Authors: Levy R, Vila M, Herrero MT, Faucheux B, Agid Y, Hirsch EC
Journal: Neuroscience Letters
Reference: 199:220-224
Year: 1995
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