Ongoing Research Projects

1. Title: Modulation of age-dependent neuromelanin accumulation as a novel therapeutic strategy for Parkinson’s disease and brain aging
Principal Investigator: Miquel Vila
Agency: “la Caixa” Banking Foundation-Health Research 2017 (Spain)
Funding: 466,004 €
Period: 2019-21

2. Title: Focused ultrasound modulation of neuromelanin accumulation in a humanized rat model of Parkinson’s disease
Principal Investigator: Miquel Vila (Co-PI: S. Lehericy, Brain & Spine Institute-ICM, Paris, France)
Agency: Network of Centres of Excellence in Neurodegeneration (CoEN)
Funding: 456,488 € (Vila group: 182,097.52 €)
Period: 2018-20

3. Title: Pathogenic Role of Neuromelanin in Parkinson’s disease and Brain Aging: Molecular Mechanisms in a Novel Humanized Pre-clinical in Vivo Model
Principal Investigator: Miquel Vila
Agency: The Michael J. Fox Foundation for Parkinson’s Research (USA)
Funding: $98,450
Period: 2018-19

4. Title: SYNUCLEAN-D: A novel molecule to cure Parkinson’s disease
Collaborator: Miquel Vila (PI: S. Ventura, UAB)
Agency: CaixaImpulse, “la Caixa” Banking Foundation (Spain)
Funding: 70,000 €
Period: 2018-19

5. Title: Diagnostic/therapeutic potential of neuromelanin in Parkinson disease using novel humanized preclinical in vivo model
Principal Investigator: Miquel Vila
Agency: Ministerio de Economía y Competitividad (MINECO, Spain)
Funding: 363,000 €
Period: 2016-20

6. Title: Identification of pathophysiological biomarkers in the prodromal/preclinical phase of Parkinson’s disease
Principal Investigator: Miquel Vila
Agency: Center for Networked Biomedical Research on Neurodegenerative Diseases (CIBERNED, Spain)
Funding: 280,000 € (Vila group: 70,000 €)
Period: 2017-18

7. Title: The gut-brain axis in prodromal Parkinson’s disease: new possibilities for risk/diagnostic biomarkers and therapeutic interventions
Principal Investigator: Ariadna Laguna
Agency: Proyectos de I+D+I para Jóvenes Investigadores-Ministerio de Economía y Competitividad (MINECO, Spain)
Funding: 170,000 €
Period: 2016-19

8. Title: Support to Consolidated Research Groups
Principal Investigator: Miquel Vila
Agency: Agència de Gestió d’Ajuts Universitaris i de la Recerca (AGAUR, Spain)
Funding: 35,200 €
Period: 2017-19

9. Title: A precise approach for nucleoside-based therapy of neuromuscular disorders with defects in mitochondrial DNA
Co-Principal Investigator: Miquel Vila (Coordinator: M.A. Martín, Hospital 12 de Octubre)
Agency: ISCIII-FEDER, Programa Desarrollo en Medicina Personalizada (Spain)
Funding: 806,223 € (Vila group: 58,000 €)
Period: 2016-19

10. Title: Adaptive immune response in Parkinson’s disease induced by alpha-synuclein proteoforms present in Lewy bodies: diagnostic and therapeutic application
Principal Investigator: Jordi Bové
Agency: Fondo de Investigación Sanitaria-Instituto de Salud Carlos III (Spain)
Funding: 134,915 €
Period: 2016-18

11. Title: Targeting a novel transcriptional pathway to reduce alpha-synuclein expression
Co-Principal Investigator: Miquel Vila (PI: S. Desagher, CNRS-Institute of Molecular Genetics Montpellier, France)
Agency: The Michael J. Fox Foundation for Parkinson’s Research (USA)
Funding: 91,400 € (Vila group: 26,624 €)
Period: 2016-18