PUBLICATIONS 2015 - present

Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson’s disease-like mouse model and in monkeys

Alarcón-Arís D, Pavia-Collado R, Miquel-Rio L, Coppola-Segovia V, Ferrés-Coy A, Ruiz-Bronchal E, Galofré M, Paz V, Campa L, Revilla R, Montefeltro A, Kordower JH, Vila M, Artigas F, Bortolozzi A.
EBioMedicine (2020) 59:102944

Validation of a Reversed Phase UPLC-MS/MS Method to Determine Dopamine Metabolites and Oxidation Intermediates in Neuronal Differentiated SH-SY5Y Cells and Brain Tissue

Gonzalez-Sepulveda M, Laguna A, Carballo-Carbajal I, Galiano-Landeira J, Romero-Gimenez J, Cuadros T, Parent A, Peñuelas N, Compte J, Nicolau A, Guillard-Sirieix C, Xicoy H, Kobayashi J, Vila M.
ACS Chemical Neuroscience (2020) 11(17):2679-87

Sex-dependent Calcium Hyperactivity Due to Lysosomal-Related Dysfunction in Astrocytes From APOE4 Versus APOE3 Gene Targeted Replacement Mice

Larramona-Arcas R, González-Arias C, Perea G, Gutiérrez A, Vitorica J, García-Barrera T, Gómez-Ariza JL,  Pascua-Maestro R, Ganfornina MD, Kara E, Hudry E, Martinez-Vicente M, Vila M, Galea E, Masgrau R.
Molecular Neurodegeneration (2020) 15(1):35

Identification of of distinc pathological signatures induced by patient-derived alpha-synuclein structures in non-human primates

Bourdenx M, Nioche A, Dovero S, Arotcarena ML, Camus S, Porras G, Thiolat ML, Rougier NP, Prigent A, Aubert P, Bohic S, Sandt C, Laferrière F, Doudnikoff E, Kruse N, Mollenhauer B, Novello S, Morari M, Leste-Lasserre T, Trigo Damas I, Goillandeau M, Perier C, Estrada C, Garcia-Carrillo N, Recasens A, Vaikath NN, El-Agnaf OMA, Herrero MT, Derkinderen P, Vila M, Obeso JA, Dehay B, Bezard E.
Science Advances 6(20):eaaz9165 (2020)

Bidirectional gut-to-brain and brain-to-gut propagation of synucleinopathy in nonhuman primates

Arotcarena ML, Dovero S, Prigent A, Bourdenx M, Camus S, Porras G, Thiolat ML, Tasselli M, Aubert P, Kruse N, Mollenhauer B, Trigo Damas I, Estrada C, Garcia-Carrillo N, Vaikath NN, El-Agnaf OMA, Herrero MT, Vila M, Obeso JA, Derkinderen P, Dehay B, Bezard E.
Brain 43(5):1462-1475 (2020)

LRRK2 in Parkinson disease: challenges of clinical trials

Tolosa E, Vila M, Klein C, Rascol O
Nature Reviews Neurology 16(2):97-107 (2020)

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

Carballo-Carbajal I.*, Laguna A.*, Romero-Gimenez J., Cuadros T., Bové J, Martinez-Vicente M., Parent A., Gonzalez-Sepulveda M., Peñuelas N., Torra A., Rodriguez-Galvan B., Ballabio A., Hasegawa T., Bortolozzi A., Gelpi E., Vila M.
Nature Communications 10(1):973 (2019)

Neuromelanin, aging and neuronal vulnerability in Parkinson’s disease

Vila M.
Movement Disorders 34(10): 1440-1451 (2019)

Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology

Vila M.,  Laguna A. , Carballo-Carbajal I.
Autophagy 15(11):2028-2030 (2019)

Parkinson disease, substantia nigra vulnerability, and calbindin expression: Enlightening the darkness?

Blesa J., Vila M.
Movement Disorders 34(2):161-163 (2019)

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