Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson’s disease-like mouse model and in monkeys
Authors: Alarcón-Arís D, Pavia-Collado R, Miquel-Rio L, Coppola-Segovia V, Ferrés-Coy A, Ruiz-Bronchal E, Galofré M, Paz V, Campa L, Revilla R, Montefeltro A, Kordower JH, Vila M, Artigas F, Bortolozzi A
Journal: EBioMedicine
Reference: 59:102944
Year: 2020
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Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson’s disease-like mouse model and in monkeys
Authors: Alarcón-Arís D, Pavia-Collado R, Miquel-Rio L, Coppola-Segovia V, Ferrés-Coy A, Ruiz-Bronchal E, Galofré M, Paz V, Campa L, Revilla R, Montefeltro A, Kordower JH, Vila M, Artigas F, Bortolozzi A
Journal: eBioMedicine
Reference: 59:102944
Year: 2020
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CD8 T cell nigral infiltration precedes synucleinopathy in early stages of Parkinson’s disease
Authors: Galiano-Landeira J, Torra A, Vila M, Bové J
Journal: Brain
Reference: 143(12):3717-33
Year: 2020
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Chitinase 3-like 1 is neurotoxic in primary cultured neurons
Authors: Matute-Blanch C, Calvo-Barreiro L, Carballo-Carbajal I, Gonzalo R, Sanchez A, Vila M, Montalban X, Comabella M
Journal: Scientific Reports
Reference: 10(1):7118
Year: 2020
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Identification of of distinc pathological signatures induced by patient-derived alpha-synuclein structures in non-human primates
Authors: 14. Bourdenx M, Nioche A, Dovero S, Arotcarena ML, Camus S, Porras G, Thiolat ML, Rougier NP, Prigent A, Aubert P, Bohic S, Sandt C, Laferrière F, Doudnikoff E, Kruse N, Mollenhauer B, Novello S, Morari M, Leste-Lasserre T, Trigo Damas I, Goillandeau M, Perier C, Estrada C, Garcia-Carrillo N, Recasens A, Vaikath NN, El-Agnaf OMA, Herrero MT, Derkinderen P, Vila M, Obeso JA, Dehay B, Bezard E
Journal: Science Advances
Reference: 6(20):eaaz9165
Year: 2020
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LRRK2 in Parkinson disease: challenges of clinical trials
Authors: Tolosa E, Vila M, Klein C, Rascol O
Journal: Nature Reviews Neurology
Reference: 16(2):97-107
Year: 2020
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Sex-dependent Calcium Hyperactivity Due to Lysosomal-Related Dysfunction in Astrocytes From APOE4 Versus APOE3 Gene Targeted Replacement Mice
Authors: Larramona-Arcas R, González-Arias C, Perea G, Gutiérrez A, Vitorica J, García-Barrera T, Gómez-Ariza JL, Pascua-Maestro R, Ganfornina MD, Kara E, Hudry E, Martinez-Vicente M, Vila M, Galea E, Masgrau R
Journal: Molecular Neurodegeneration
Reference: 15(1):35
Year: 2020
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Validation of a Reversed Phase UPLC-MS/MS Method to Determine Dopamine Metabolites and Oxidation Intermediates in Neuronal Differentiated SH-SY5Y Cells and Brain Tissue
Authors: Gonzalez-Sepulveda M, Laguna A, Carballo-Carbajal I, Galiano-Landeira J, Romero-Gimenez J, Cuadros T, Parent A, Peñuelas N, Compte J, Nicolau A, Guillard-Sirieix C, Xicoy H, Kobayashi J, Vila M.
Journal: ACS Chemical Neuroscience
Reference: 11(17):2679-87
Year: 2020
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Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis
Authors: Carballo-Carbajal I, Laguna A, Romero-Gimenez J, Cuadros T, Bové J, Martinez-Vicente M, Parent A, Gonzalez-Sepulveda M, Peñuelas N, Torra A, Rodriguez-Galvan B, Ballabio A, Hasegawa T, Bortolozzi A, Gelpi E, Vila M
Journal: Nature Communications
Reference: 10(1):973
Year: 2019
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Intracellular crowding by age-dependent neuromelanin accumulation disrupts neuronal proteostasis and triggers Parkinson disease pathology
Authors: Vila M, Laguna A, Carballo-Carbajal I
Journal: Autophagy
Reference: 15(11):2028-2030
Year: 2019
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Neuromelanin, aging and neuronal vulnerability in Parkinson’s disease
Authors: Vila M
Journal: Movement Disorders
Reference: 34(10):1440-1451
Year: 2019
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Parkinson disease, substantia nigra vulnerability, and calbindin expression: Enlightening the darkness?
Authors: Blesa J, Vila M.
Journal: Movement Disorders
Reference: 34(2):161-163
Year: 2019
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Defective mitochondrial protein import contributes to complex I-induced mitochondrial dysfunction and neurodegeneration in Parkinson’s disease
Authors: Franco-Iborra S, Cuadros T, Parent A, Romero-Gimenez J, Vila M*, Perier C*
Journal: Cell Death & Disease
Reference: 9(11):1122
Year: 2018
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Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons
Authors: Urrea L, Segura-Feliu M, Masuda-Suzukake M, Hervera A, Pedraz L, Aznar JM, Vila M, Samitier J, Torrents E, Ferrer I, Gavín R, Hagesawa M, Del Río JA
Journal: Molecular Neurobiology
Reference: 55(3):1847-1860
Year: 2018
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Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients
Authors: Recasens A, Carballo-Carbajal I, Parent A, Bové J, Gelpi E, Tolosa E, Vila M.
Journal: Acta Neuropathologica Communications
Reference: 6(1):8
Year: 2018
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Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson’s disease and Huntington’s disease
Authors: Franco-Iborra S, Vila M*, Perier C*
Journal: Frontiers in Neuroscience
Reference: 12:342
Year: 2018
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Overexpression of TFEB drives a pleiotropic neurotrophic effect and prevents Parkinson’s disease-related neurodegeneration
Authors: Torra A, Parent A, Cuadros T, Rodríguez-Galván B, Ruiz-Bronchal E, Ballabio A, Bortolozzi A, Vila M*, Bové J*
Journal: Molecular Therapy
Reference: 26(6):1552-1567
Year: 2018
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Selective alpha-Synuclein Knockdown in Monoamine Neurons by Intranasal Oligonucleotide Delivery: Potential Therapy for Parkinson disease
Authors: Alarcón-Arís D, Recasens A, Galofré M, Carballo-Carbajal I, Zacchi N, Ruiz-Bronchal E, Pavia-Collado R, Chica R, Ferrés-Coy A, Santos M, Revilla R, Montefeltro A, Fariñas I, Artigas F, Vila M*, Bortolozzi A*
Journal: Molecular Therapy
Reference: 26(2):550-567
Year: 2018
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Synaptic regulator α-synuclein in dopaminergic fibers is essentially required for the maintenance of subependymal neural stem cells
Authors: Perez-Villalba A, Salomé Sirerol-Piquer M, Belenguer G, Soriano-Cantón R, Belén Muñoz-Manchado A, Villadiego J, Alarcón-Arís D, Soria FN, Dehay B, Bezard E, Vila M, Bortolozzi A, José Toledo-Aral J, Pérez-Sánchez F, Fariñas I
Journal: Journal of Neuroscience
Reference: 38(4):814-825
Year: 2018
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The E3 ubiquitin-ligases TRIM17 and TRIM41 modulate α-synuclein expression by regulating ZSCAN21
Authors: Lassot I, Mora S, Lesage S, Zieba B, Coque E, Condroyer C, Bossowski JP, Mojsa B, Marelli C, Tesson C, Carballo-Carbajal I, Laguna A, Mangone G, Vila M, Brice A, Desagher S.
Journal: Cell Reports
Reference: 25(9):2484-2496.e9
Year: 2018
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The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against α-Synuclein-Induced Toxicity
Authors: 29. Kim H, Calatayud C, Guha S, Fernández-Carasa I, Berkowitz L, Carballo-Carbajal I, Ezquerra M, Fernández-Santiago R, Kapahi P, Raya A, Miranda-Vizuete A, Lizcano JM, Vila M, Caldwell KA, Caldwell GA, Consiglio A, Dalfo E
Journal: Molecular Neurobiology
Reference: 55(9):7553-7554
Year: 2018
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Cerebellar neurodegeneration in a new rat model of episodic hepatic encephalopathy
Authors: García-Lezana T, Oria M, Romero-Giménez J, Bové J, Vila M, Genescà J, Chavarria L and Cordoba J
Journal: Journal of Cerebral Blood Flow and Metabolism
Reference: 37(3):927-937
Year: 2017
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Glucocerebrosidase deficiency in dopaminergic neurons induces microglial activation without neurodegeneration
Authors: Soria FN, Engeln M, Martinez-Vicente M, Glangetas C, Lopez-Gonzalez MJ, Dovero S, Dehay B, Normand E, Vila M, Favereaux A, Georges F, Lo Bianco C, Bezard E, Fernagut Po
Journal: Human Molecular Genetics
Reference: 26(14):2603-2615
Year: 2017
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Alpha-synuclein propagation: New insights from animal models
Authors: Dehay B, Vila M, Bezard E, Brundin P, Kordower JH
Journal: Movement Disorders
Reference: 31(2):161-8
Year: 2016
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Functional rescue of dopaminergic neuron loss in Parkinson’s disease mice after transplantation of hematopoietic stem and progenitor cells.
Authors: Altarche-Xifro W, di Vicino U, Muñoz-Martin MI, Bortolozzi A, Bové J, Vila M, Cosma MP
Journal: EBioMedicine
Reference: 8:83-95
Year: 2016
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Authors: Klionsky DJ, Martinez-Vicente, Vila M et al
Journal: Autophagy
Reference: 12(1):1-222
Year: 2016
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The Parkinson disease mitochondrial hypothesis: where are we at?
Authors: Franco-Iborra S, Vila M, Perier C
Journal: Neuroscientist
Reference: 22(3):266-77
Year: 2016
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Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson disease patients
Authors: Fernández-Santiago R, Carballo-Carbajal I, Castellano G, Torrent R, Richaud Y, Sánchez-Danés A, Vilarrasa R, Sánchez-Pla A, Mosquera JL, Soriano J, López-Barneo J, Canals JM, Alberch J, Raya A, Vila M, Consiglio A, Martín-Subero JI, Ezquerra M, Tolosa E
Journal: EMBO Molecular Medicine
Reference: 7(12):1529-46
Year: 2015
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Targeting α-synuclein for treating Parkinson’s disease: mechanistic and therapeutic considerations
Authors: Dehay B, Bourdenx M, Gorry P, Przedborski S, Vila M, Hunot S, Singleton A, Olanow CW, Merchant KM ,Bezard E, Petsko GA, Meissner WG
Journal: Lancet Neurology
Reference: 14(8):855-66
Year: 2015
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BAX channel activity mediates lysosomal disruption linked to Parkinson disease
Authors: Bové J, Martínez-Vicente M., Dehay B, Perier C, Recasens A, Bombrun A, Antonsson B, Vila M
Journal: Autophagy
Reference: 10(5):889-900
Year: 2014
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DYRK1A promotes dopaminergic neuron survival in the developing brain and in a mouse model of Parkinson’s disease
Authors: Barallobre MJ, Perier C, Bové J, Laguna A, Delabar JM, Vila M, Arbonés ML
Journal: Cell Death & Disease
Reference: 5:e1289
Year: 2014
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Lewy Body extracts from Parkinson’s Disease Brains trigger α-Synuclein Pathology and Neurodegeneration in Mice and Monkeys
Authors: Recasens A, Dehay B, Bové J, Carballo-Carbajal I, Dovero S, Pérez A, Fernagut PO, Blesa J, Parent A, Perier C, Fariñas I, Obeso JA, Bezard E, Vila M
Journal: Annals of Neurology
Reference: 75(3):351-62
Year: 2014
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Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms
Authors: Perier C, Bender A, García-Arumí E, Melià MJ, Bové J, Laub C, Klopstock T, Elstner M, Mounsey RB, Teismann P, Prolla T, Andreu AL, Vila M
Journal: Brain
Reference: 136:2369-78
Year: 2013
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Alpha-synuclein and protein degradation pathways in Parkinson’s disease: A pathological feed-back loop
Authors: Martinez-Vicente M, Vila M
Journal: Experimental Neurology
Reference: 247:308-13
Year: 2013
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Lysosomal impairment in Parkinson’s disease
Authors: Dehay B, Martinez-Vicente M, Caldwell GA, Caldwell KA, Yue Z, Cookson MR, Klein C, Vila M, Bezard E
Journal: Movement Disorders
Reference: 28(6)725-32
Year: 2013
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Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency
Authors: Ramonet D, Perier C, Recasens A, Dehay B, Bové J, Costa V, Scorrano L, Vila M.
Journal: Cell Death & Differentiation
Reference: 20(1):77-85
Year: 2013
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Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson’s disease
Authors: Sánchez-Danés A, Richaud-Patin Y, Carballo-Carbajal I, Jiménez-Delgado S, Gaig C, Mora S, Di Guglielmo C, Ezquerra M, Patel B, Giralt A, Canals JM, Memo M, Alberch J, López-Barneo J, Vila M, Cuervo AM, Tolosa E, Consiglio A, Raya A
Journal: EMBO Molecular Medicine
Reference: 4(5):380-95
Year: 2012
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Efficient Generation of A9 Midbrain Dopaminergic Neurons by Lentiviral Delivery of LMX1A in Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
Authors: Sánchez-Danés A, Consiglio A, Richaud Y, Rodríguez-Pizà I, Dehay B, Edel M, Bové J, Memo M, Vila M, Raya A, Izpisua-Belmonte JC.
Journal: Human Gene Therapy
Reference: 23(1):56-69
Year: 2012
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Guidelines for the use and interpretation of assays for monitoring autophagy
Authors: Klionsky DJ, Martinez-Vicente M, Vila M et al
Journal: Autophagy
Reference: 8(4):445-544
Year: 2012
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Loss of ATP13A2/PARK9 induces general lysosomal deficiency: implications for Parkinson’s disease
Authors: Dehay B, Ramirez A, Martinez-Vicente M, Perier C, Canron MH, Doudnikoff E, Vital A, Vila M, Klein C, Bezard E
Journal: Proceedings of the National Academy of Sciences USA
Reference: 109(24):9611-6
Year: 2012
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Lysosomal dysfunction in Parkinson disease: ATP13A2 gets into the groove
Authors: Dehay B, Martinez-Vicente M, Ramirez A, Perier C, Klein C, Vila M, Bezard E
Journal: Autophagy
Reference: 8(9):1389-91
Year: 2012
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Mitochondria and programmed cell death in Parkinson’s disease: apoptosis and beyond
Authors: Perier C, Bové J, Vila M
Journal: Antioxidants & Redox Signaling
Reference: 16(9):883-95
Year: 2012
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Mitochondrial biology and Parkinson’s disease
Authors: Perier C, Vila M
Journal: Cold Spring Harbor Perspectives in Medicine
Reference: 2(2):a009332
Year: 2012
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Selective neuroprotective effects of the S18Y polymorphic variant of UCH-L1 in the dopaminergic system
Authors: Xilouri M, Kyratzi E, Pitychoutis PM, Papadopoulou-Daifoti Z, Perier C, Vila M, Maniati M, Ulusoy A, Kirik D, Park DS, Wada K, Stefanis L
Journal: Human Molecular Genetics
Reference: 21(4):874-89
Year: 2012
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Fighting neurodegeneration with rapamycin: mechanistic insights
Authors: Bové J, Martínez-Vicente M, Vila M
Journal: Nature Reviews Neuroscience
Reference: 12(8):437-52
Year: 2011
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Lysosomal membrane permeabilization in Parkinson’s Disease
Authors: Vila M, Bové J, Dehay B, Rodríguez-Muela N, Boya P
Journal: Autophagy
Reference: 7(1):98-100
Year: 2011
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Oligomeric α-synuclein is toxic in vivo
Authors: Vila M
Journal: Movement Disorders
Reference: 26(9):1616
Year: 2011
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Apoptosis inducing factor deficiency sensitizes dopaminergic neurons to parkinsonian neurotoxins
Authors: Perier C, Bové J, Dehay, B, Jackson-Lewis V, Rabinovitch P., Przedborski, S, Vila M
Journal: Annals of Neurology
Reference: 68:184-192
Year: 2010
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Pathogenic lysosomal depletion in Parkinson’s Disease
Authors: Dehay B, Bové J, Rodríguez-Muela N, Perier C, Recasens A, Boya P, Vila M
Journal: Journal of Neuroscience
Reference: 30(37):12535-12544
Year: 2010
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Selective noradrenergic vulnerability in alpha-synuclein transgenic mice
Authors: Sotiriou E, Vassilatis DK, Vila M, Stefanis L
Journal: Neurobiology of Aging
Reference: 31(12):2103-14
Year: 2010
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