Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson’s disease
Authors: Hoang T, Choi DK, Nagai M, Wu DC, Nagata T, Prou D, Wilson GL, Vila M, Jackson-Lewis V, Dawson VL, Dawson TM, Chesselet MF, Przedborski S
Journal: Free Radical Biology and Medicine
Reference: 47(7):1049-56
Year: 2009
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Mitochondrial alterations in Parkinson’s disease: new clues
Authors: Vila M, Ramonet D, Perier C
Journal: Journal of Neurochemistry
Reference: 107:317-328
Year: 2008
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Molecular pathways of programmed cell death in experimental Parkinson’s disease
Authors: Vila M, Perier C
Journal: Parkinsonism & Related Disorders
Reference: 14 Suppl 2:S176-9
Year: 2008
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Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson’s disease
Authors: Perier C, Bove J, Wu DC, Jackson-Lewis V, Dehay B, Choi DG, Rathke-Hartlieb S, Bouillet P, Strasser A., Schulz JB, Przedborski S, Vila M
Journal: Proceedings of the National Academy of Sciences USA
Reference: 104(19):8161-6
Year: 2007
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Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson’s disease
Authors: Choi DK, Pennathur S, Perier C, Tieu K, Teismann P., Wu DC, Jackson-Lewis V, Vila M, Von Sattel JP, Heinecke JW, Przedborski S
Journal: Journal of Neuroscience
Reference: 25(28):6594-600
Year: 2005
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Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage
Authors: Perier C, Tieu K, Guegan C, Caspersen C, Jackson-Lewis V, Carelli V, Martinuzzi A, Hirano M, Przedborski S, Vila M
Journal: Proceedings of the National Academy of Sciences USA
Reference: 102(52):19126-19131
Year: 2005
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Genetic clues to the pathogenesis of Parkinson’s disease
Authors: Vila M, Przedborski S
Journal: Nature Medicine
Reference: 10 Suppl:S58-62
Year: 2004
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Interfering with programmed cell death in neurodegenerative diseases: insights from experimental animal models (Letter to Editor)
Authors: Vila M
Journal: Drug Discovery Today
Reference: 9(12):513-514
Year: 2004
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JNK-mediated induction of COX-2 is required for neurodegeneration in a mouse model of Parkinson’s disease
Authors: Hunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, Rakic P, Flavell RA
Journal: Proceedings of the National Academy of Sciences USA
Reference: 101(2): 665-70
Year: 2004
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MPTP as a Mitochondrial Neurotoxic Model of Parkinson’s disease
Authors: Przedborski S, Tieu K, Perier C, Vila M
Journal: Journal of Bioenergetics and Biomembranes
Reference: 36(4):375-9
Year: 2004
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Neurodegeneration: what does it mean?
Authors: Vila M
Journal: Neurología
Reference: 19(3):89-91
Year: 2004
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Apoptosis as therapeutic target
Authors: Vila M
Journal: Neurología
Reference: 18:186-193
Year: 2003
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COX-2 and Neurodegeneration in Parkinson’s Disease
Authors: Teismann P, Vila M, Choi DK, Tieu K, Wu DC, Jackson-Lewis V, Przedborski S
Journal: Annals of the New York Academy of Sciences
Reference: 991:272-7
Year: 2003
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Cyclooxygenase-2 is instrumental in Parkinson disease neurodegeneration
Authors: Teismann P, Tieu K, Choi DK, Wu DC, Naini A, Hunot S, Vila M, Jackson-Lewis V, Przedborski S
Journal: Proceedings of the National Academy of Sciences USA
Reference: 100(9):5473-8
Year: 2003
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D-ß-hydroxybutyrate rescues mitochondrial respiration and mitigates features of Parkinson’s disease
Authors: Tieu K, Caspersen C, Teismann P, Wu DC, Perier C, Naini A, Vila M, Jackson-Lewis V, Ramasamy R, Przedborski S
Journal: Journal of Clinical Investigation
Reference: 112(6):892-901
Year: 2003
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Free radicals and nitric oxide toxicity in Parkinson’s disease
Authors: Przedborski S, Jackson-Lewis V, Vila M, Wu DC, Teismann P, Tieu K, Choi DG, Cohen O
Journal: Advances in Neurology
Reference: 91:83-94
Year: 2003
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Neurodegeneration: what is it and where are we?
Authors: Przedborski S, Vila M, Jackson-Lewis V
Journal: Journal of Clinical Investigation
Reference: 111(1):3-10
Year: 2003
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Neurotoxic contribution of NADPH oxidase-derived oxidative stress in the MPTP model of Parkinson’s disease
Authors: Wu DC, Teismann P, Tieu K, Vila M, Jackson-Lewis V, Ischiropoulos H, Przedborski S
Journal: Proceedings of the National Academy of Sciences USA
Reference: 100(10):6145-50
Year: 2003
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Overexpression of HAHD II/ABAD rescues mitochondrial respiration and dopaminergic neurons in the MPTP model of Parkinson’s disease
Authors: Tieu K, Perier C, Vila M, Zhang HP, Teismann P, Caspersen C, Jackson-Lewis V, Stern DM, Yan SD, Przedborski S
Journal: Annals of Neurology
Reference: 56(1):51-60.
Year: 2003
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Pathogenic role of glial cells in Parkinson’s Disease
Authors: Teismann P, Tieu K, Cohen O, Choi DK, Wu DC, Marks D, Vila M, Jackson-Lewis V, Przedborski S
Journal: Movement Disorders
Reference: 18(2):121-9
Year: 2003
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Targeting programmed cell death in neurodegenerative diseases
Authors: Vila M, Przedborski S
Journal: Nature Reviews in Neuroscience
Reference: 4(5):365-75
Year: 2003
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The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson’s disease
Authors: Przedborski S, Vila M
Journal: Annals of the New York Academy of Sciences
Reference: 991:189-98
Year: 2003
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The rotenone model of Parkinson’s disease
Authors: Perier C, Bové J, Vila M, Przedborski S
Journal: Trends in Neuroscience
Reference: 26(7):345-6
Year: 2003
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Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
Authors: Wu DC, Jackson-Lewis V, Vila M, Tieu K, Teismann P, Vadseth C, Choi DK, Ischiropoulos H, Przedborski S
Journal: Journal of Neuroscience
Reference: 22(5):1763-71
Year: 2002
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Glial cell response: A pathogenic factor in Parkinson’s disease
Authors: Wu DC, Tieu K, Cohen O, Choi DK, Vila M, Jackson-Lewis V, Teismann P, Przedborski S
Journal: Journal of Neurovirology
Reference: 8:551-8
Year: 2002
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Increased Expression and Redistribution of the Antiapoptotic Molecule Bcl-x(L) in Parkinson’sDisease
Authors: Hartmann A, Mouatt-Prigent A, Vila M, Abbas N, Perier C, Faucheux BA, Vyas S, Hirsch EC
Journal: Neurobiology of Disease
Reference: 10(1):28-32
Year: 2002
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Instrumental activation of Bid by caspase-1 in a transgenic mouse model of ALS
Authors: Guegan C, Vila M, Teismann P, Chen C, Onténiente B, Li M, Friedlander RM, Przedborski S
Journal: Molecular and Cellular Neuroscience
Reference: 20(4):553-562
Year: 2002
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Resistance of alpha-synuclein null mice to the parkinsonian neurotoxin MPTP
Authors: Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen K, Staal R, Tieu K, Schmitz Y, Yuan CA, Jackson-Lewis V, Hersch S, Sulzer D, Przedborski S, Burke R, Hen R
Journal: Proceedings of the National Academy of Sciences USA
Reference: 99:14524-14529
Year: 2002
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Tyrosine hydroxylase
Authors: Jackson-Lewis V, Vila M, Przedborski S
Journal: Wiley Encyclopedia of Molecular Medicine
Reference: 3283-3293
Year: 2002
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Bax ablation prevents dopaminergic neurodegeneration in the MPTP mouse model of Parkinson disease
Authors: Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, Offen D, Korsmeyer SJ, Przedborski S.
Journal: Proceedings of the National Academy of Sciences USA
Reference: 98(5):2837-42
Year: 2001
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Engineered modeling and the secrets of Parkinson’s disease
Authors: Vila M, Wu DC, Przedborski S
Journal: Trends in Neuroscience
Reference: 24(11):S49-S55
Year: 2001
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Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter
Authors: Matsuoka Y*, Vila M*, Lincoln S, McCormack A, Picciano M, LaFrancois J, Yu X, Dickson D, Langston WJ, McGowan E, Farrer M, Hardy J, Duff K, Przedborski S, Di Monte DA
Journal: Neurobiology of Disease
Reference: 8:535-539
Year: 2001
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LY293558, an AMPA glutamate receptor antagonist, prevents and reverses levodopa-induced motor fluctuations in parkinsonian rats
Authors: Marin C, Jiménez A, Bonastre M, Vila M, Hirsch EC, Agid Y, Tolosa E
Journal: Synapse
Reference: 42(1): 40-47
Year: 2001
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MPTP: a review of its mechanisms of neurotoxicity
Authors: Przedborski S, Vila M
Journal: Clinical Neuroscience Research
Reference: 1(6):407-418
Year: 2001
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Oxidative post-translational modifications of alpha-synuclein in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease
Authors: Przedborski S, Chen Q, Vila M, Giasson BI, Djaldetti R, Vukosavic S, Souza JM, Jackson-Lewis V, Lee VMY, Ischiropoulos H
Journal: Journal of Neurochemistry
Reference: 76:637-640
Year: 2001
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Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis
Authors: Guegan C, Vila M, Rosoklija G, Hays AP, Przedborski S
Journal: Journal of Neuroscience
Reference: 21(17):6569-6576
Year: 2001
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The last decade in Parkinson’s disease research: basic sciences
Authors: Przedborski S, Vila M
Journal: Advances in Neurology
Reference: 86:177-186
Year: 2001
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The role of glial cells in Parkinson’s disease
Authors: Vila M, Jackson-Lewis V, Guegan C, Teismann P, Wu DC, Choi DG, Tieu K, Przedborski S
Journal: Current Opinion in Neurology
Reference: 14:483-489
Year: 2001
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A new look at the pathogenesis of Parkinson’s disease
Authors: Przedborski S, Vila M, Jackson-Lewis V, Dawson TM
Journal: Trends in Pharmacological Sciences
Reference: 21(5):165
Year: 2000
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Alpha-Synuclein upregulation in substantia nigra dopaminergic neurons following the administration of the parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Authors: Vila M, Vukosavic S, Jackson-Lewis V, Jakowec M, Przedborski S
Journal: Journal of Neurochemistry
Reference: 74:721-729
Year: 2000
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Developmental cell death in dopaminergic neurons of the substantia nigra of mice
Authors: Jackson-Lewis V, Vila M, Djaldetti R, Guegan C, Liberatore G, Liu J, O’Malley KL, Burke RE, Przedbosrki S
Journal: Journal of Comparative Neurology
Reference: 424(3):476-488
Year: 2000
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Functional activity of zona incerta neurons is altered after nigrostriatal denervation in hemiparkinsonian rats
Authors: Perier C, Vila M, Feger J, Agid Y, Hirsch EC
Journal: Experimental Neurology
Reference: 162(1):215-224
Year: 2000
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Metabolic activity of excitatory parafascicular and pedunculopontine inputs to subthalamic nucleus in a rat model of Parkinson’s disease
Authors: Orieux G, François C, Feger J, Yelnik J, Vila M, Ruberg M, Agid Y, Hirsch EC
Journal: Neuroscience
Reference: 97(1):79-88
Year: 2000
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Metabolic changes in the basal ganglia following nigrostriatal denervation
Authors: Hirsch EC, Périer C, Orieux G, François C., Féger J, Yelnik J, Vila M, Levy R, Tolosa E, Marin C, Herrero MT, Obeso JA, Agid Y
Journal: Trends in Neuroscience
Reference: 23(10 Suppl):S78-85
Year: 2000
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The indirect basal ganglia pathway in dopamine D(2) receptor-deficient mice
Authors: Murer MG, Dziewczapolski G, Saline P, Vila M, Tseng KY, Ruberg M, Rubinstein M, Kelly MA, Grandy DK, Low MJ, Hirsch EC, Raisman-Vozari R, Gershanik O
Journal: Neuroscience
Reference: 99(4):643-50
Year: 2000
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The parkinsonian toxin MPTP: action and mechanism
Authors: Przedborski S, Jackson-Lewis V, Djaldetti R, Liberatore G, Vila M, Vukosavic S, Almer G
Journal: Restorative Neurology and Neuroscience
Reference: 16(2):135-142
Year: 2000
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Time course changes in metabolic and electrophysiologic neuronal activity in the subthalamic nucleus of rats with unilateral lesion of the substantia nigra
Authors: Vila M, Perier C, Feger J, Yelnik J, Faucheux B, Ruberg M, Raisman-Vozari R, Agid Y, Hirsch EC
Journal: European Journal of Neuroscience
Reference: 12(1):337-344
Year: 2000
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Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease
Authors: Liberatore GT, Jackson Lewis V, Vukosavic S, Mandir AS, Vila M, McAuliffe WJ, Dawson VL, Dawson TM, Przedborski S
Journal: Nature Medicine
Reference: 5(12):1403-1409
Year: 1999
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Systemic administration of NMDA and AMPA receptor antagonists reverses the neurochemical changes induced by nigrostriatal denervation in basal ganglia
Authors: Vila M, Marin C, Ruberg M, Jimenez A, Raisman-Vozari R, Agid Y, Tolosa E, Hirsch EC
Journal: Journal of Neurochemistry
Reference: 73:344-352
Year: 1999
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Consequences of nigrostriatal denervation on the functioning of the basal ganglia in human and non-human primates: an in situ hybridization study of cytochrome oxidase subunit I mRNA
Authors: Vila M, Levy R, Herrero MT, Ruberg M, Faucheux B, Obeso JA, Agid Y, Hirsch EC.
Journal: Journal of Neuroscience
Reference: 17(2):765-773
Year: 1997
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